Volume: 56 Issue: 3
Year: 2025, Page: 476-481, Doi: https://doi.org/10.51966/jvas.2025.56.3.476-481
Received: April 26, 2025 Accepted: July 18, 2025 Published: Sept. 30, 2025
Fipronil is a broad-spectrum phenyl pyrazole insecticide commonly used in agricultural, veterinary, and household practices. The present study was carried out to investigate the histopathological alterations induced by fipronil in the lungs of male Wistar albino rats and its amelioration with pomegranate peel extract. A total of 24 rats were divided into four groups with six animals in each group. Group I served as a control group provided with adlibitum feed and distilled water. Group II animals were treated with 10 mg/kg b. wt. fipronil orally for 45 days, group III animals were treated with pomegranate peel extract at 200 mg/kg b. wt. and group IV animals were treated with both fipronil (@ 10mg/kg b. wt.) and pomegranate peel extract (@ 200 mg/kg b. wt.) during the experimental period. Histopathological examination of lungs of fipronil-treated rats showed severe degenerative changes like hyperplastic and hyaline arteriosclerotic changes, degenerated and desquamated bronchial epithelium, perivascular oedema, mononuclear aggregates, etc. These changes were alleviated after administering Punica granatum peel extract along with fipronil which clearly indicates the protective effect of pomegranate peel extract against pulmonary injury induced by fipronil.
Keywords: Fipronil, histopathology, pulmonary toxicity, male Wistar albino rats, pomegranate peel extract.
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© 2025 Nakul et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0
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Nakul, P., Sujatha, K., Anand Kumar, A. and Vijayalakshmi, S. 2025. Protective effects of Pomegranate Peel Extract (PPE) against fipronil-induced lung toxicity in Wistar Albino Rats.
J. Vet. Anim. Sci. 56 (3):476-481