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Partial genome analysis of cox1 subunit-I region in mitochondrial dna of canine mammary tumours
K. Krithiga, Arathi Rajan, Geetu Rose Varghese, R.L. Neetha, Dipyaman Patra, Neethu Krishnan, Arathy Warrier and Priya Srinivas

doi: https://doi.org/10.51966/jvas.2021.52.1.95-98

Journal of Veterinary and Animal Sciences.2021. 52(1):95-98.

Author Details

K. Krithiga: PhD Scholar, CRP-6, Rajiv Gandhi Centre for Biotechnology, Research Centre, University of Kerala, Thiruvananthapuram, India.

Arathi Rajan: PhD Scholar, CRP-6, Rajiv Gandhi Centre for Biotechnology, Research Centre, University of Kerala, Thiruvananthapuram, India.

Geetu Rose Varghese: PhD Scholar, CRP-6, Rajiv Gandhi Centre for Biotechnology, Research Centre, University of Kerala, Thiruvananthapuram, India.

R.L. Neetha: PhD Scholar, CRP-6, Rajiv Gandhi Centre for Biotechnology, Research Centre, University of Kerala, Thiruvananthapuram, India.

Dipyaman Patra: PhD Scholar, CRP-6, Rajiv Gandhi Centre for Biotechnology, Research Centre, University of Kerala, Thiruvananthapuram, India.

Neethu Krishnan: PhD Scholar, CRP-6, Rajiv Gandhi Centre for Biotechnology, Research Centre, University of Kerala, Thiruvananthapuram, India.

Arathy Warrier: PhD Scholar, CRP-6, Rajiv Gandhi Centre for Biotechnology, Research Centre, University of Kerala, Thiruvananthapuram, India.

Priya Srinivas: Scientist F, Rajiv Gandhi Centre for Biotechnology, Research Centre, University of Kerala, Thiruvananthapuram, India. 

Article History

Received: 25.09.2020, Accepted: 14.10.2020, Published online: 01.01.2021

Corrersponding author: Priya Srinivas

e-mail: priyasrinivas@rgcb.res.in

 

 

Citation: Krithiga, K., ArathiRajan, Geetu Rose Varghese, Neetha, R.L., DipyamanPatra, Neethu Krishnan, ArathyWarrier and PriyaSrinivas. Partial genome analysis of Cox1 subunit-I region in mitochondrial DNA of canine mammary tumours. J. Vet. Anim. Sci. 52(1): 95-98.



Abstract


Oncogenesis is an area which continuously elicits research interest. There are innumerable factors which contribute to oncogenesis of which mitochondrial DNA (mtDNA) mutations play a major role. Though extensive studies have been conducted relating mtDNA mutations to human cancers, there is sparse information available on canine neoplasia. Cytochrome oxidase1 (COX1) is an important component of electron transport chain of mitochondria and any alteration in it would result in altered energy production which is very essential for proliferating neoplastic cells. Two samples of canine mammary carcinomas (CMT) were subjected to partial genome sequencing of COX1 subunit -I. There was no change in the gene sequence of COX1. Further studies in this aspect would pave the way for investigations on the role of mtDNA mutation in oncogenesis and could provide insights into how canines can serve as models for human cancers.

Keywords: Canine mammary tumour, mtDNA, mutation