Volume: 52 Issue: 4
Year: 2021, Page: 409-413, Doi: https://doi.org/10.51966/jvas.2021.52.4.409-413
Received: March 8, 2021 Accepted: May 30, 2021 Published: Dec. 15, 2021
Coagulatory abnormalities are common in renal dysfunction in humans. The studies on coagulatory abnormalities in renal failure in dogs are limited. The present paper deals with coagulation profile in acute and chronic kidney disease in dogs. The haemostatic defects observed in acute renal dysfunction included thrombocytopaenia, prolonged capillary bleeding time (CBT), elevated D-Dimer and hypoantithrombinemia which indicated a hypercoagulable state. Prolongation of prothrombin time (PT), activated partial thromboplastin time (aPTT), elevated D-Dimer concentration and hypoantithrombinemia in chronic kidney disease indicated the presence of hypocoagulable state.
Keywords: Coagulation profile, nephropathy, dog
Dorgalaleh, A., Mahmudi, M., Tabibian, S., Khatib, Z. K., Tamaddon, G. H., Moghaddam, E. S., Bamedi, T., Alizadeh, S. and Moradi, E. 2013. Anemia and thrombocytopenia in acute and chronic renal failure. Int. J. Hematol. Stem. Cell Res.7: 34-39.
Huang, M.J., Wei, R.B., Wang, Y., Su, T.Y., Di, P., Li, Q.P., Yang, X., Li, P. and Chen, X.M., 2017. Blood coagulation system in patients with chronic kidney disease: a prospective observational study. B. M. J.open 7: 1-7.
Kumar, V., Kumar, A. and Varshney, A. C. 2011. Ultrasonographic Imaging for Structural Characterization of Renal Affections and Diagnosis of Associated Chronic Renal Failure in 10 Dogs. I. S. R. N. Vet. Sci. 2011: 1–11.
Mcbride, D. J. R. E., Stefano, C and chan, D. L. 2019. Primary hemostatic function indogs with acute kidney injury.J. Vet. Int. Med.33: 2029–2036.
Mischke, R., 2014. Laboratory evaluation and interpretation of haemostasis in small animals. J. Hellenic Vet. Med. Soc. 65: 165-180.
Nagel, S.S., Schoeman, J.P., Thompson, P.N., Wiinberg, B. and Goddard, A. 2014. Hemostatic analysis of dogs naturally envenomed by the African puffadder (Bitis arietans) and snouted cobra (Naja annulifera). J. Vet. Emerg. Crit. Care. 24: 662-671.
Nayanakumara, S. 2016. Clinico-pathologicalin vestigationsonsnakeenvenomationindo gs. MVSc thesis,KeralaVeterinaryandA nimalSciencesUniversity. Pookode. 88p.
Ozmen, C. A., Akin, D., Bilek, S. U., Bayrak, A. H., Senturk, S. and Nazaroglu, H. 2010. Ultrasound as a diagnostic tool to differentiate acute from chronic renal failure.Clin.Nephrol.74: 46-52.
Polzin, D. J., Osborne, C. A., Jacob, F and Ross, S. 2000. Chronic renal failure.In: Ettinger, S. J. and Feldman, E. C. (ed.), Textbook of Veterinary Internal Medicine: Diseases of the Dog and Cat. (2nd Ed.). Elsevier Saunders, Philadelphia, pp.1734-1760.
Rubin, S. I. and Carr, A. P. 2007.Canine Internal Medicine Secrets.(1st Ed.). Elsevier, Missouri, 464p.
Shah, S.A., 2013.Haemostatic defects in chronic kidney disease. J. Med. Sci. 21: 149-152.
Trompouki, E., Mullen, L., Fernandez-Reyes, D., Yodoi, J., Kim, S. and Schuettpelz, L.G. 2017.Inflammatory Signaling in Bone Marrow Failure and Hematopoietic Malignancy. Front.immunol. 8: 660.
Vikrant, S., Jaryal, A. and Parashar, A. 2017. Clinicopathological spectrum of snake bite-induced acute kidney injury from India. Wld. J. Nephrol.6: 150-161.
© 2021 Anjaly et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Anjaly, M. V., Sindhu, K. R., Usha, N. P., Ajithkumar, S. and Justin Davis, K. 2021. Coagulation profile in two nephropathic dogs. J. Vet. Anim. Sci. 52(4):409-413
DOI: https://doi.org/10.51966/jvas.2021.52.4.409-413