Volume: 51 Issue: 2
Year: 2020, Page: 175-178,
Received: Aug. 20, 2019 Accepted: Sept. 25, 2019 Published: July 1, 2020
Oxidativestressmanagementhasbeenfoundtohavebeneficialeffects inthemanagement of several disease conditions. A study was conducted to evaluate the efficacy of Coenzyme Q10 supplementation on the total antioxidant status and lipid peroxides levels in dogs with chronic valvular heart disease.Total antioxidant status was measured by Ferric Reducing Antioxidant Power assay and level of lipid peroxides in serum was determined by estimating malonaldialdehyde level. Ten dogs with chronic chronic valvular heart disease were administered with coenzyme Q10 @ 45mg q12h orally for 60 days along with the treatment for management of valvular heart disease.A significant decline in Ferric Reducing Antioxidant Power value was recorded at the end of the study. The malonaldialdehyde levels declined in animals with chronic valvular heart disease by day 60, though reduction was not statistically significant.The administration of Coenzyme Q10 in chronic valvular heart disease may be beneficial in improving the quality of life of the patient.
Keywords: Dog, Coenzyme Q10, Chronic valvular heart disease, Oxidative stress
Benzie, I.F.F. and Strain, J.J. 1996. The ferric reducing ability of plasm (FRAP) as a measure of antioxidant power: The FRAP assay. Analyt. Biochem. 239: 70- 76.
Doehner, W. and Anker, S.D.2005. Uric acid in chronic heart failure. Semin. Nephrol. 25:61-66.
Freeman, L. M., Rush, J. E., Milbury, P. E. and Blumberg, J. E. 2005. Antioxidant status and biomarkers of oxidative stress in dogs with congestive heart failure. J.Vet. Intern. Med. 19:537-541.
Haggstrom, J., Pedersen, H.D. and Kvart, C. 2004. New insights into degenerative mitral valve disease in dogs. Vet. Clin. North Am. Small Anim. Pract. 34:1209- 1226.
Hare, J.M. and Johnson, R.J., 2003. Uric acid predicts clinical outcomes in heart failure: insights regarding the role of xanthine oxidase and uric acid in disease pathophysiology. Circulation.107:1951- 1953.
Hetyey, C.S., Manczur, F., Dudas-Gyorki, Z., Reiczigel, J., Ribiczey, P., Vajdovich, P. and Voros, K. 2007. Plasma antioxidant capacity in dogs with naturally occurring heart diseases. Transbound. Emerg. Dis. 54:36-39.
Khan, A., Shah, M.H., Khan, S., Shamim, U. and Arshad, S., 2017. Serum uric acid level in the severity of congestive heart failure (CHF). Pak. J. Med. Sci. 33:330- 334.
Lee, B.J., Huang, Y.C., Chen, S.J. and Lin, P.T. 2011. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease. Nutrition. 28:250-255.
Littarru, G.P. and Tiano, L. 2007. Bioenergetic and antioxidant properties of coenzymeQ10: recent developments. Mol. Biotech. 37: 31-37.
Liu, H.T., Huang, Y.C., Cheng, S.B., Huang, Y.T. and Lin, P.T. 2015. Effects of coenzyme Q10 supplementation on antioxidant capacity and inflammation in hepatocellular carcinoma patients after surgery: a randomized, placebocontrolled trial. Nutr. J. 15:85-94.
Maheshwari, R.A., Balaraman, R., Sen, A.K. and Seth, A.K. 2014. Effect of coenzyme Q10 alone and its combination with metformin on streptozotocin-nicotinamide-induced diabetic nephropathy in rats. Indian J. Pharmacol. 46:627-632.
Moazen, M., Mazloom, Z., Ahmadi, A., Dabbaghmanesh, M.H. and Roosta, S. 2015. Effect of coenzyme Q10 on glycaemic control, oxidative stress and adiponectin in type 2 diabetes. J. Pak. Med. Ass. 65:404-408.
Prasad, K., Gupta, J.B., Kalra, J., Lee, P., Mantha, S.V. and Bharadwaj, B. 1996. Oxidative stress as a mechanism of cardiac failure in chronic volume overload in canine model. J. Mol. Cell. Cardiol. 28:375-385.
Reimann, M.J., Moller, J.E., Haggstrom, J., Martinussen, T., Zatrazemi, S.S.C., Svanholm, L., Nielsen, L.B.M., Pedersen, H.D. and Olsen, L.H. 2017. Mitral regurgitation severity and left ventricular systolic dimension predict survival in young Cavalier King Charles Spaniels. J. Vet. Intern. Med. 31:1008- 1016.
Sharma, A., Patnai, P. and Mehta, N.D.P. 2016. Effect of Coenzyme Q10 alone and it’s Combination with Pentoxifylline in Cisplatin-Induced Nephrotoxicity in Rats. J. Pharm. Sci. Bioscientific Res.6: 790-800.
Yagi, K. 1984. Assay for blood plasma or serum. Methods Enzymol.105: 328-331.
© 2020 Revathi et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Revathi, K., Madhavan Unny, N., Usha, N.P., Uma, R. and Ajithkumar, S.2020. Effect of coenzyme q10 supplementation on total antioxidant status and lipid peroxides levels in dogs with chronic valvular heart disease. J.Vet. Anim. Sci. 51(2): 175-178.