Volume: 54 Issue: 2
Year: 2023, Page: 419-427, Doi: https://doi.org/10.51966/jvas.2023.54.2.419-427
Received: Nov. 9, 2022 Accepted: Dec. 28, 2022 Published: June 30, 2023
The present study was conducted to investigate electrocardiographical (ECG) and haemato-biochemical changes in arrhythmia associated with renal diseases in dogs. The dogs with renal affections confirmed through appropriate diagnostic methods were selected and screened for arrhythmia. The ECG and haemato-biochemical parameters of twenty dogs with arrhythmia were compared with that of the control group and ECG parameters were statistically correlated with the haemato-biochemical parameters for correlation studies. It was found that the occurrence of arrhythmia was 51.2 per cent in renal diseases. Arrhythmia was more predominant in dogs with chronic kidney disease (CKD) followed by acute kidney injury (AKI). Sinus arrhythmia followed by first-degree AV block and wandering pacemaker were the common types of arrhythmias observed. A significant increase in R-R interval and a decrease in heart rate was noticed in comparison. The haemato-biochemical analysis revealed anaemia, leukocytosis with neutrophilia, elevated blood urea nitrogen (BUN), creatinine and magnesium level. A significant positive correlation was noticed between haemoglobin, volume of packed red cells (VPRC) and red blood cell count (RBC) with T amplitude and, creatinine and BUN levels with corrected Q-T interval. A significant negative correlation was noticed between VPRC, RBC and haemoglobin with the corrected QT interval. The present study revealed ECG and haemato-biochemical parameters had a significant role in renal diseases in dogs which might help in the early diagnosis and proper management of arrhythmia associated with renal diseases
Keywords: Renal disease, Arrhythmia, electrocardiography, correlation studies
Akhtar, Z., Leung, L.W., Kontogiannis, C., Chung, I., Waleed, K.B. and Gallagher, M.M. 2022. Arrhythmias in Chronic Kidney Disease. Eur. Cardiol. [online]. 17 (5). Available: doi: 10.15420/ecr.2021.52 [7 Mar. 2022].
Akoum, N., Zelnick, L.R., de Boer, I.H., Hirsch, I.B., Trence, D., Henry, C., Robinson, N. and Bansal, N. 2019. Rates of cardiac rhythm abnormalities in patients with CKD and diabetes. Clin. J. Am. Soc. Nephrol. 14: 549-556.
Alfonso, A., Le Sueur, A.N., Geraldes, S.S., Guimaraes-Okamoto, P.T., Tsunemi, M.H., Santana, D.F., Ribeiro, V.R., Melchert, A., Chiacchio, S.B. and Lourenço, M.L.G. 2020. Heart rate variability and electrocardiographic parameters predictive of arrhythmias in dogs with Stage IV chronic kidney disease undergoing intermittent haemodialysis. Animals, 10: 1-14.
Alpert, M.A. and Ravenscraft, M.D. 2003. Pericardial involvement in end-stage renal disease. Am. J. M. Sc. 325: 228-236.
Anjaly, M.V., Sindhu, K.R., Usha, N.P., Ajithkumar, S. and Davis, K.J., 2021. Coagulation profile in two nephropathic dogs. J. Vet. Anim. Sci. 52: 409-413.
Bagshaw, S.M., Hoste, E.A., Braam, B., Briguori, C., Kellum, J.A., McCullough, P.A., Ronco, C. 2013. Cardiorenal syndrome type 3: pathophysiologic and epidemiologic considerations. In: ADQI Consensus on AKI Biomarkers and Cardiorenal Syndromes. Karger Publishers, 182: 137-157.
de Lima, C.S., Ferreira, K.R.G., Borin-Crivellenti, S., Maia, S.R., Santana, A.E. and Crivellenti, L.Z. 2022. Renal Magnesium Handling: A Comparison between dogs with chronic kidney disease and healthy elderly dogs. Top. Companion Anim. Med. 46: 588-597.
Elias, J., Kuniyoshi, R., Moulin, B., Cunha, F., Castro, E., Nunes, A., Barreto, V., Queiroz, A. and Moyses, F. 2004. Syncope and complete atrioventricular block related to pulmonary thromboembolism. Arq. Bras. Cardiol. 83: 434-438.
Ferreira, C., Providência, R., Ferreira, M.J. and Gonçalves, L.M. 2015. Atrial fibrillation and non-cardiovascular diseases: a systematic review. Arq. Bras. Cardiol. 105: 519-526.
Keller, S.P., Kovacevic, A., Howard, J., Schweighauser, A. and Francey, T. 2016. Evidence of cardiac injury and arrhythmias in dogs with acute kidney injury. J. Small Anim. Pract. 57: 402-408.
Korzets, A., Ori, Y. and Herman, M. 2001. Serum potassium levels and atrial fibrillation in haemodialysis patients. Nephrol. Dial. Transplant. 16: 1090-1091.
Lazzerini, P.E., Capecchi, P.L. and Laghi-Pasini, F. 2015. Long QT syndrome: an emerging role for inflammation and immunity. Front. Cardiovasc. Med. 2: 1-17.
Madjid, M., Awan, I., Willerson, J.T. and Casscells, S.W. 2004. Leukocyte count and coronary heart disease: implications for risk assessment. J. Am. Coll. Cardiol. 44: 1945-1956.
Manev. I. 2021. Cardiac arrhythmias in canine patients with renal insufficiency. Tradit. Mod. Vet. Med. 6: 21-24.
Mozos, I. 2014. Laboratory Markers of Ventricular Arrhythmia Risk in Renal Failure. BioMed Res. Int. [online]. 2014. Available: https://doi.org/10.1155/2014/5092042014: 509204. [26 May. 2014].
Perini-Perera, S., Del-Angel-Caraza, J., Perez-Sanchez, A.P., Quijano-Hernandez, I.A. and Recillas-Morales, S. 2021. Evaluation of chronic kidney disease progression in dogs with therapeutic management of risk factors. Front. Vet. Sci. 8: 1-10.
Pouchelon, J.L., Atkins, C.E., Bussadori, C., Oyama, M.A., Vaden, S.L., Bonagura, J.D., Chetboul, V., Cowgill, L.D., Elliot, J., Francey, T. and Grauer, G.F. 2015. Cardiovascular–renal axis disorders in the domestic dog and cat: a veterinary consensus statement. J. Small Anim. Pract. 56: 537-552.
Ravi, V., Iskander, F., Saini, A., Brecklin, C. and Doukky, R. 2018. Clinical predictors and outcomes of patients with pericardial effusion in chronic kidney disease. Clin. Cardiol. 41: 660-665.
Rubinger, D., Revis, N., Pollak, A., Luria, M.H. and Sapoznikov, D. 2004. Predictors of haemodynamic instability and heart rate variability during haemodialysis. Nephrol. Dial. Transplant. 19: 2053-2060.
Scheller, B., Pipa, G., Kertscho, H., Lauscher, P., Ehrlich, J., Habler, O., Zacharowski, K. and Meier, J. 2011. Low hemoglobin levels during normovolemia are associated with electrocardiographic changes in pigs. Shock. 35: 375-381.
Sonu, A.K., Charaya, G., Bangar, Y., Agnihotri, D. and Kumar, T. 2019. Haemato-biochemical alterations in dogs suffering from chronic renal failure. Indian J. Vet. Med. 39: 31-35.
Tilley, L.P. and Smith, F.W.K. 2007. Renal failure. In: Blackwell’s Five Minute Veterinary Consult. (3rd Ed.). Blachwell Publising, USA, 1186-1189.
Varshney, J.P., 2020. Cardiac Evaluation Approaches. In Electrocardiography in Veterinary Medicine. (1st Ed.). Springer, Singapore, 3-23.
Vishnurahav, R.B., Ajithkumar, S., Usha, N.P., Unny, N.M., Martin, K.J., Aravindakshan, T.V. and Sunanda, C., 2018. Electrocardiographic, radiographic and blood pressure changes in dogs with dilated cardiomyopathy. J. Vet. Anim. Sci. 49: 83-86.
© 2023 Krishna et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are
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Krishna, R.U.S., George, A., Pillai, U. N., Rajan, S. K. and Nair, S. N. 2023. Evaluation of electrocardiographic and serum biochemical changes in arrhythmias associated with renal diseases of dogs. J. Vet. Anim. Sci. 54(2):419-427
DOI: https://doi.org/10.51966/jvas.2023.54.2.419-427