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Journal of Veterinary and Animal Sciences

Volume: 57 Issue: 1

  • Open Access
  • Research Article

Evaluation of haemodynamic stability during multimodal total intravenous anaesthesia with etomidate in dogs having cardiovascular diseases

Aiswarya Babu1, Soumya Ramankutty1, Syam, K. Venugopal1, S. Anoop1, B. M. Nijin Jos 1, Sindhu K. Rajan2 and V. L. Gleeja3

1Department of Veterinary Surgery and Radiology, 2Department of Veterinary Clinical Medicine Ethics and Jurisprudence,
3Department of Biostatistics College of Veterinary and Animal Sciences, Mannuthy, Thrissur, Kerala-680651, Kerala
Veterinary and Animal Sciences University Kerala, India

Year: 2026, Page: 98-103, Doi: https://doi.org/10.51966/jvas.2026.57.1.98-103

Received: Sept. 12, 2025 Accepted: Dec. 1, 2025 Published: March 31, 2026

Abstract

The present study was conducted in six dogs with the objective of evaluation of the haemodynamic stability of total intravenous anaesthesia with etomidate and constant rate infusion with ketamine-lignocaine for maintaining anaesthesia in dogs having cardiovascular diseases. The dogs presented for various surgical procedures were subjected to routine clinical examination and cardiovascular evaluation. Following this, six dogs with cardiovascular diseases, presented for various soft tissue surgical procedures, were selected for the study. The cardiovascular diseases identified were mitral valvular disease, dilated cardiomyopathy, pre-clinical dilated cardiomyopathy and left ventricular hypertrophy. All the anaesthetic medications were given intravenously. The dogs were pre-anaesthetised with butorphanol and diazepam. Etomidate was given for anaesthetic induction. Ketamine at sub-anaesthetic doses and lignocaine were given for analgesia. Injection ketamine-lignocaine was administered as CRI for maintaining analgesia. Cardiovascular stability was assessed through the monitoring of vital signs, saturation of peripheral oxygen, end-tidal carbon dioxide, blood pressure and ECG. Eye ball position, pupil size and signs of nociception were also monitored. All the anaesthetic parameters were within the physiological limit with no significant difference during different periods of observation. The present protocol provided the required cardiovascular stability for the successful completion of all the six surgeries.

Keywords: Anaesthesia, Etomidate, Cardiovascular diseases

References

Andreoni, V., & Hughes, J. L. (2009). Propofol and fentanyl infusions in dogs of various breeds undergoing surgery. Veterinary Anaesthesia and Analgesia, 36, 523–531.

Babu, A. C., Ramankutty, S., Nair, S. S., Panicker, V. P., & Martin, K. J. (2023). Evaluation of haematological and serum biochemical profile of geriatric dogs undergoing a multimodal anaesthesia protocol. Journal of Veterinary and Animal Sciences, 54, 330–335.

Bodh, D., Singh, K., Mohindroo, J., Mahajan, S. K., & Saini, N. S. (2015). Sedative, analgesic and cardiopulmonary effects of midazolam–butorphanol premedication in water buffaloes (Bubalus bubalis). Buffalo Bulletin, 34, 29–40.

Brown, S. A., & Henrik, R. A. (2016). Systemic hypertension. In F. W. K. Smith Jr., L. P. Tilley, M. A. Oyama, & M. M. Sleeper (Eds.), Manual of canine and feline cardiology (5th ed., pp. 275–284). Elsevier.

Chaudhary, A. R. (2021). Clinical studies of balanced anaesthetic protocols using atropine sulphate–pentazocine–diazepam as pre-anaesthetics, propofol/etomidate as induction agents and isoflurane as maintenance anaesthetic in dogs (Doctoral thesis). Kamdhenu University, Navsari, India.

Congdon, J. M. (2015). Cardiovascular diseases. In L. B. C. Snyder & R. A. Johnson (Eds.), Canine and feline anesthesia and co-existing disease (1st ed., pp. 250–260). Wiley-Blackwell.

Côté, E. (2010). Electrocardiography and cardiac arrhythmias. In S. J. Ettinger & E. C. Feldman (Eds.), Veterinary internal medicine (7th ed., pp. 1159–1187). Saunders Elsevier.

Dar, S. H., Jayaprakash, R., George, R. S., Nissar, S., Shafiuzamma, M., & Kannan, T. A. (2019). The anaesthetic effect of propofol or etomidate in geriatric dogs premedicated with butorphanol and diazepam. Veterinarski Arhiv, 89, 831–838.

Dewangan, R., & Tiwari, S. K. (2015). Total intravenous anaesthesia (TIVA) in veterinary practice. International Journal of Scientific Research, 5, 1533–1539.

Dinesh, R. S., Tayal, R., Chaudhary, R. N., & Kumar, A. (2019). Evaluation of efficacy and safety of atropine–midazolam–pentazocine with propofol/ketamine for induction and isoflurane for maintenance of anaesthesia in dogs undergoing orthopaedic surgical procedures. Journal of Pharmaceutical Innovation, 8, 111–117.

Djuric, M., Kostic, S., Nikolic Turnic, T., Stankovic, S., Skrbic, R., Djuric, D. M., & Stevanovic, P. (2020). Comparison of the effects of ketamine and etomidate on cardiodynamics, biochemical and oxidative stress parameters in Wistar male rats. Molecular and Cellular Biochemistry, 474, 125–134.

Epstein, M. E. (2015). Opioids. In J. S. Gaynor & W. W. Muir (Eds.), Handbook of veterinary pain management (2nd ed., pp. 161–195). Mosby.

Forman, S. A. (2011). Clinical and molecular pharmacology of etomidate. Anesthesiology, 114, 695–707.

Grubb, T. L., Perez Jimenez, T. E., & Pettifer, G. R. (2015). Senior and geriatric patients. In K. A. Grimm, L. A. Lamont, W. J. Tranquilli, S. A. Greene, & S. A. Robertson (Eds.), Veterinary anesthesia and analgesia (5th ed., pp. 496–510). John Wiley & Sons.

Hareesh, A. U. (2016). Clinical evaluation of etomidate and propofol anaesthesia following atropine, diazepam and fentanyl premedication in geriatric dogs (Doctoral thesis). Sri Venkateswara Veterinary University, Tirupati, India.

Hellyer, P. W., Robertson, S. A., & Fails, A. D. (2007). Pain and its management. In W. J. Tranquilli, J. C. Thurmon, & K. A. Grimm (Eds.), Lumb & Jones’ veterinary anesthesia and analgesia (4th ed., pp. 31–57). Blackwell Publishing.

Lersch, F., Correia, P. C., Hight, D., Kaiser, H. A., & Berger-Estilita, J. (2023). The nuts and bolts of multimodal anaesthesia in the 21st century: A primer for clinicians. Current Opinion in Anaesthesiology, 36, 666–675.

Love, E. J., Taylor, P. M., Whay, H. R., & Murrell, J. (2013). Postcastration analgesia in ponies using buprenorphine hydrochloride. Veterinary Record, 172, 635.

Nascimento, J. D. S., Modolo, N. S. P., Silva, R. C. R., Santos, K. P., & Carvalho, H. G. D. (2007). Sedative and cardiovascular effects of midazolam and diazepam alone or combined with clonidine in patients undergoing hemodynamic studies for suspected coronary artery disease. Arquivos Brasileiros de Cardiologia, 89, 403–408.

Pedersen, T., Møller, A. M., & Pedersen, B. D. (2003). Pulse oximetry for perioperative monitoring: Systematic review of randomized controlled trials. Anesthesia & Analgesia, 96, 426–431.

Perkowski, S. Z., & Oyama, M. A. (2015). Pathophysiology and anaesthetic management of patients with cardiovascular disease. In K. A. Grimm et al. (Eds.), Veterinary anesthesia and analgesia (5th ed., pp. 988–992). John Wiley & Sons.

Ramankutty, S. (2024). Multimodal analgesic protocols as an adjunct to balanced anaesthesia for management of somatic and visceral pain associated with soft tissue surgery in dogs: A comparative evaluation (Doctoral thesis). Kerala Veterinary and Animal Sciences University, Pookode, India.

Rodríguez, J. M., Muñoz-Rascón, P., Navarrete-Calvo, R., Gómez-Villamandos, R. J., Pérez, J. M. D., Sarmiento, J. A. F., Carmona, S. Q., & Machuca, M. M. G. (2012). Comparison of the cardiopulmonary parameters after induction of anaesthesia with alphaxalone or etomidate in dogs. Veterinary Anaesthesia and Analgesia, 39, 357–365.

Stephan, A. V. (2024). Comparative evaluation of intraperitoneal and intravenous lignocaine in a multimodal anaesthetic protocol for ovariohysterectomy in dogs (Master’s thesis). Kerala Veterinary and Animal Sciences University, Pookode, India.

Tilley, L. P., & Smith, F. W. K., Jr. (2016). Electrocardiography. In F. W. K. Smith Jr., L. P. Tilley, M. A. Oyama, & M. M. Sleeper (Eds.), Manual of canine and feline cardiology (5th ed., pp. 49–76). Elsevier.

Trenholme, H. N., & Pang, D. (2024). Principles of anesthetic monitoring and monitoring equipment. In G. E. Zeiler & D. S. J. Pang (Eds.), Fundamental principles of veterinary anesthesia (1st ed., pp. 49–60). John Wiley & Sons.

White, P. F., & Kehlet, H. (2010). Improving postoperative pain management: What are the unresolved issues? Anesthesiology, 112, 220–225.

Ware, W. A. (2011). Myocardial diseases of the dog. In Cardiovascular diseases in small animal medicine (2nd ed.). Manson Publishing.

Cite this article

Babu, A., Ramankutty, S., Syam, K. V., Anoop, S., Nijin, J. B. M., Sindhu, K. R. & Gleeja, V.L. (2025). Evaluation of haemodynamic stability during multimodal total intravenous anaesthesia with etomidate in dogs having cardiovascular diseases. Journal of Veterinary and Animal Sciences 57 (1),98-103 https://doi.org/10.51966/jvas.2026.57.1.98-103

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