JVAS announces awards - Four best research articles (one each from basic, production, para-clinical and clinical subjects) and one best short communication will be adjudged for awards each year!!!

Journal of Veterinary and Animal Sciences

Volume: 52 Issue: 4

  • Open Access
  • Research Article

Haemato-biochemical changes in tuberculosis infected and healthy Asian elephants (Elephas maximus) from South India

M. Ranjini*1, P. M. Deepa1, K. Vijayakumar2, A. Janus1 and K. Karthyayini3

1. Department of Veterinary Epidemiology and Preventive Medicine, College of Veterinary and Animal Sciences, Pookode- 673576 Kerala Veterinary and Animal Sciences University, Kerala, India.

2. Department of Veterinary Epidemiology and Preventive Medicine, College of Veterinary and Animal Science, Mannuthy

3. Department of Veterinary Physiology, College of Veterinary and Animal Science, Mannuthy

*Corresponding author, Email: [email protected] Phone: 08078421265

Year: 2021, Page: 345-349, Doi: https://doi.org/10.51966/jvas.2021.52.4.345-349

Received: Feb. 10, 2021 Accepted: March 26, 2021 Published: Dec. 15, 2021

Abstract

Tuberculosis is known to be a disease of elephants for the past 2000 years. The main causative agent isolated from reported tuberculosis (TB) cases were Mycobacterium tuberculosis. The study focuses on the haematological and serum biochemical changes in the blood of TB infected Asian elephants (Elephas maximus). Twelve apparently healthy elephants and twelve TB infected elephants (confirmed by trunk wash smear positive for acid fast bacilli) were selected for the study. Neonates, pregnant elephants and elephants in musth were not included in the study. The study animals were subjected to haematological and serum biochemical evaluation. The data were analysed statistically. The results showed a significant increase in total leukocyte count, lymphocyte count, monocyte count, thrombocyte count and ESR in TB affected animals compared with apparently healthy animals. Serum creatinine, total bilirubin, direct bilirubin, globulin was significantly high in TB affected animals compared with healthy controls. Assessment of haematological and serum biochemical parameters in TB affected elephants aid in diagnosis and tracking of the infection.

Keywords: Elephant, tuberculosis, haematology, serum biochemistry

References

Abay, F., Yalew, A., Shibabaw, A. and Enawgaw, B. 2018. Hematological abnormalities of pulmonary tuberculosis patients with and without HIV at the University of Gondar Hospital, Northwest Ethiopia: a comparative cross-sectional study. Tuberc. Res. Treat. 5740951. https://doi.org/10.1155/2018/5740951

Abdelkareem, Y., Hashim, A.M. and Abdelazeem, H. 2015. Hematological changes in pulmonary tuberculosis. AlAzhar Assiut Med. J. 13: 224-229.

Cheesbrough, M. 2005. District laboratory practice in tropical countries. (2nd ed.) Cambridge university press. 331p.

Giri, K., Kaufman, G.E. and Dhakal, I.P. 2011. The relationship between blood parameter and mycobacterium culture status in captive elephants of Nepal. Nepalese Vet. J. 30: 119-129.

Kahase, D., Solomon, A. and Alemayehu, M. 2020. Evaluation of Peripheral Blood Parameters of Pulmonary Tuberculosis Patients at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia: Comparative Study. J. Blood Med. 11:115-121.

Kerr, M. G. 2002. Laboratory Medicine Clinical Biochemistry and Haematology. Blackwell Scientific publications Ltd., Great Britain. 2nd ed. 127-135p.

Lewerin, S.S., Eld, K., Bölske, G., Olsson, S.L., Röken, B., Ghebremichael, S., Koivula, T. and Källenius, G. 2005. Outbreak of Mycobacterium tuberculosis infection among captive Asian elephants in a Swedish zoo. Vet. Rec. 156:171-175.

Mandal, S.K. and Chavan, L. 2016. Erythrocyte sedimentation rate values in cases of active tuberculosis without HIV coinfection. J. Med. Sci. clin. Res. 4:13156- 13159.

Mikota, S.K., Peddie, L., Peddie, J., Isaza, R., Dunker, F., West, G., Lindsay, W. and Larsen, R.S. 2001. Epidemiology and diagnosis of Mycobacterium tuberculosis in captive Asian elephants (Elephas maximus). J. Zoo Wildl. Med. 32: 1-16.

Miner, M.D., Chang, J.C., Pandey, A.K., Sassetti, C.M. and Sherman, D.R. 2009. Role of cholesterol in Mycobacterium tuberculosis infection. Indian J. Exp. Biol.47: 407-411.

Oliva, V.M., Cezário, G.A.G., Cocato, R.A. and Marcondes-Machado, J. 2008. Pulmonary tuberculosis: hematology, serum biochemistry and the relation with the disease duration. J. Venom. Anim. Toxins incl. Trop. Dis. 14: 71-81.

Ottenhoff, T.H. 2012. New pathways of protective and pathological host defense to mycobacteria. Trends Microbiol. 20: 419-428.

Rathod, S., Samel, D.R., Kshirsagar, P. and Pokar, M. 2017. Thrombocytosis: can it be used as a marker for tuberculosis. Int. J. Res. Med. Sci. 5: 3082-3086.

Rohini, K., Bhat, M.S., Srikumar, P.S. and Kumar, A.M. 2016. Assessment of hematological parameters in pulmonary tuberculosis patients. Indian J. Clin. Biochem. 31:332-335.

Shingdang, J., Bot, Y., Ojo, O., Edeh,O., Essien,C., Bwende, E., Okolie, C. and Ekwempu, A.I. 2016. Serum Albumin/ Globulin ratio in Tuberculosis and HIV Patients any Relationship?. Mycobact. Dis. 6:199.

Wong, C.T. and Saha, N. 1989. Serum immunoglobulin and acute phase protein concentrations in pulmonary tuberculosis patients in Singapore. Trop. Geogr. Med. 41: 218-221. 

Yaranal, P.J., Umashankar, T. and Harish, S.G. 2013. Hematological profile in pulmonary tuberculosis. Int. J. Health Rehabil. Sci. 2: 50-55.

Cite this article

Ranjini, M., Deepa, P. M., Vijayakumar, K., Janus, A. and Karthyayini, K. 2021. Haematobiochemical changes in tuberculosis infected and healthy Asian elephants (Elephas maximus) from South India. J. Vet. Anim. Sci. 52(4): 345-349

DOI: https://doi.org/10.51966/jvas.2021.52.4.345-349

Views
133
Downloads
30
Citations