Volume: 52 Issue: 1
Year: 2021, Page: 1-6, Doi: https://doi.org/10.51966/jvas.2021.52.1.1-6
Received: Nov. 17, 2020 Accepted: Nov. 28, 2020 Published: Jan. 1, 2021
Lysosomes play a pivotal role in cellular processes through an active interplay of enzymes, lysosomal membrane proteins, and cytosolic proteins. Lysosomal storage diseases are a group of inherited and acquired disorders. Clinically affected animals are presented with developmental and neurological symptoms. This review aims to discuss the function of lysosomes, the pathogenesis of lysosomal storage disease, and its diagnosis.
Keywords:
Alroy, J. and Lyons, J.A. 2014. Lysosomal storage disease. J. Inborn Errors Met. & Screening. 2: 1-20.
Alroy, J., Orgad, U., Ucci, A. A., Schelling, S. H., Schunk, K. L., Warren, C. D., Raghavan, S. S. and Kolodny, E. H. 1985. Neurovisceral and skeletal GM1-gangliosidosis in dogs with beta-galactosidase deficiency. Science, 229(4712): 470-472.
Alroy, J. and Ucci A.A. 2006. Skin biopsy: a useful tool in the diagnosis of lysosomal storage diseases. Ultrastruct. Pathol. 30(6): 489-503.
Ballabio, A. and Gieselmann, V. 2009. Lysosomal disorders: from storage to cellular damage. Biochimica et Biophysica Acta (BBA)-Mol. Cell Res. 1793(4), 684-696.
De Maria, R., Divari, S., Bo, S., Sonnino, S., Lotti, D., Capucchio, M. T. and Castagnaro, M. 1998. Beta-galactosidase deficiency in a Korat cat: a new form of feline GM1-gangliosidosis. Acta Neuropathol. 96(3): 307-314.
Ferreira, C. R. and Gahl, W. A. 2017. Lysosomal storage diseases. Transl. Sci. Rare Dis. 2(1-2): 1-71.
Jezyk, P.F., Haskins, M.E. and Newman, L.R. 1986. Alpha-mannosidosis in a Persian cat. J. Am. Vet. Med. Assoc., 189(11): 1483-1485.
Jolly, R. D. and Walkley, S. U. 1997. Lysosomal storage diseases of animals: an essay in comparative pathology. Vet. Pathol. 34(6): 527-48.
Kumar V., Abbas A.K., Aster J.C. and Fausto N. 2010. Robins and Cotran (editors). Pathologic Basis of Disease. 8th Ed. Saunders, Philadelphia, 1464p.
Luzio, J.P., Pryor, P.R. and Bright, N.A. 2007. Lysosomes: fusion and function. Nat. Rev. Mol. Cell Biol.. 8(8): 622-32.
Marques, A.R.A. and Saftig P. 2019. Lysosomal storage disorders - challenges, concepts and avenues for therapy: beyond rare diseases. J. Cell Sci. 132(2).
Meikle, P.J., Fietz, M.J. and Hopwood, J.J. 2004. Diagnosis of lysosomal storage disorders: current techniques and future directions. Expert Rev. Mol. Diagn. 4(5): 677-691.
Saftig, P. and Klumperman, J. 2009. Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function. Nat. Rev. Mol. Cell Biol. 10(9): 623-635.
Skelly, B. J. and Franklin, R. J. 2002. Recognition and diagnosis of lysosomal storage diseases in the cat and dog. J. Vet. Intern. Med. 16(2): 133-41.
Vicini, D. S., Wheaton, L. G., Zachary, J. F. and Parker, A. J. 1988. Peripheral nerve biopsy for diagnosis of globoid cell leukodystrophy in a dog. J. Am. Vet. Med. Assoc. 192(8): 1087-1090.
Wenger, D. A., Victoria, T., Rafi, M. A., Luzi, P., Vanier, M. T., Vite, C., Patterson, D. F. and Haskins, M. H. 1999. Globoid cell leukodystrophy in cairn and West Highland white terriers. J Hered. 90(1): 138- 142.
Walkley, S.U. 2009. Pathogenic cascades in lysosomal disease-Why so complex? J. Inherit. Metab. Dis. 32: 181-189.
© 2021 Smitha. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Georgy, S.R. 2021. Lysosomal storage diseases. J. Vet. Anim. Sci. 52(1): 1-6.
DOI: https://doi.org/10.51966/jvas.2021.52.1.1-6