Volume: 54 Issue: 1
Year: 2023, Page: 86-90, Doi: https://doi.org/10.51966/jvas.2023.54.1.86-90
Received: Sept. 12, 2022 Accepted: Dec. 27, 2022 Published: March 31, 2023
The present study was conducted to evaluate the alterations in oxidative stress parameters in dogs suffering from haemorrhagic gastroenteritis (HGE). Dogs presented with vomiting and diarrhoea were screened and fifteen animals with signs suggestive of HGE were included in the study. The oxidative stress parameters, serummalondialdehyde (MDA) level, total antioxidant status (TAS) and plasma glutathione peroxidase (GSH-Px) activity were studied. The values were compared with the values from six apparently healthy dogs. A significant increase was noticed in the mean values of serum MDA and TAS of diseased animals at the time of presentation when compared to healthy animals whereas the activity of plasma GSH-Px was found to be lower than in healthy dogs. Supplementation with N-acetyl cysteine @ 70 mg/kg or five days was found effective in managing the oxidative injury in the affected animals.
Keywords: Haemorrhagic gastroenteritis, oxidative stress, N-acetyl cysteine
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© 2023 Krishna Nath et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Krishna Nath,M.R., Madhavan Unny,N., Sindhu,K.R., Usha,N.P. and Ramnath,V. 2023. Evaluation of oxidative stress and efficacy of antioxidant therapy in dogs with haemorrhagic gastroenteritis. J. Vet. Anim. Sci. 54(1):86-90
DOI: https://doi.org/10.51966/jvas.2023.54.1.86-90