Volume: 53 Issue: 3
Year: 2022, Page: 380-384, Doi: https://doi.org/10.51966/jvas.2022.53.3.380-384
Received: Jan. 31, 2022 Accepted: March 19, 2022 Published: Sept. 30, 2022
Brain is a vital organ that always has high oxygen demands and is highly vulnerable to injury caused by reactive oxygen species (ROS). The hippocampus is a complex structure seen deep in the temporal lobe which is constituted by the dentate gyrus, hippocampus proper (Cornu Ammonis- CA1-CA4) and subiculum. The important functions of the hippocampus are learning and memory. Age-influenced pathological lesions in the hippocampus and variation in the number of neurons in the hilus are the main discussion of this study. The major gross lesions observed in the brain of both younger and older dogs were cerebral congestion, thickened meninges and cerebral edema. The major histopathological findings in the hippocampus were thickened blood vessels, accumulation of lipofuscin pigments in the neuronal cytoplasm, satellitosis, gliosis, , neurons with the vesicular nucleus, chromatolysis and neuronophagia. A statistically significant reduction in the number of neurons in the hilar region of the hippocampus was observed in aged dogs.
Keywords: Dog, hippocampus, age, neuron loss, hilus
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© 2022 Dhanya et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Dhanya, T., Prasanna, K. S., Hamza, P., Anoopraj, R., Pradeep, M., Elizabeth. V., Alin, M. T. K and Ajith, J. G. 2022. Influence of age on the pathology of hippocampus and variation in the number of neurons of the hilar region in the brain of dogs. J. Vet. Anim. Sci. 53(3): 380-384
DOI: https://doi.org/10.51966/jvas.2022.53.3.380-384